Gpr75 Deletion in Adipocytes Protects From Diet-Induced Obesity: Changes in Glucose Homeostasis and Inflammatory Responses - PubMed
3 days ago
- #glucose homeostasis
- #obesity
- #GPR75
- GPR75 deletion in adipocytes protects mice from diet-induced obesity (DIO).
- Female adipo-Gpr75-/- mice showed a 50% decrease in weight gain and adiposity compared to wild-type (WT) mice.
- Male adipo-Gpr75-/- mice gained weight similarly to WT mice, indicating sexual dimorphism in the response.
- Both male and female adipo-Gpr75-/- mice exhibited improved glucose handling and increased insulin sensitivity in skeletal muscle.
- No differences in food intake were observed, but adipo-Gpr75-/- mice had increased activity and energy expenditure.
- Adipocyte-derived GPR75 contributes to DIO by promoting inflammation, impairing insulin signaling, and disrupting metabolic homeostasis.