Propolis in Obesity and Related Metabolic Disorders: Mechanistic and Clinical Insights-A Scoping Review - PubMed
7 hours ago
- #propolis
- #metabolic disorders
- #obesity
- Propolis, a bee-derived product rich in phenolic and flavonoid compounds, is being studied for its potential effects on obesity and related metabolic disorders.
- The review synthesizes evidence from in vitro, in vivo, and clinical studies, focusing on adipogenesis, lipid and glucose metabolism, oxidative stress, and gut microbiota modulation.
- Preclinical models show propolis may modulate antioxidant defenses, inflammatory signaling, adipogenic transcriptional programs, and gut microbiota composition.
- Clinical evidence suggests modest improvements in metabolic and inflammatory biomarkers, but effects on body weight and adiposity are inconsistent.
- Heterogeneity in propolis type, extraction methods, chemical standardization, dosing, and study design limits interpretation of results.
- Current evidence indicates propolis may influence obesity-related metabolic pathways, primarily through biomarker modulation, but long-term clinical efficacy requires further research.