Microbial signatures in psoriatic arthritis distinguish disease phenotypes and newly diagnosed inflammatory bowel disease independent of faecal calprotectin - PubMed
3 hours ago
- #Inflammatory Bowel Disease
- #Psoriatic Arthritis
- #Microbiome
- Microbial signatures in psoriatic arthritis (PsA) help distinguish disease phenotypes and newly diagnosed inflammatory bowel disease (IBD) independent of faecal calprotectin (fCAL).
- Axial PsA shows lower microbiome diversity, loss of commensals, and depletion of microbial biotin and arginine metabolism compared to peripheral PsA.
- Patients with axial PsA have higher levels of proinflammatory cytokines like IL-23, IL-17F, and IL-8.
- Newly diagnosed IBD in PsA patients is characterized by depletion of tryptophan and vitamin B6 metabolism.
- Specific microbial taxa are enriched in IBD patients with a larger effect size than fCAL, suggesting potential biomarkers.
- The study identifies distinct microbiome and immune profiles in axial PsA and IBD, independent of fCAL.