Serum Concentration-Dependent Inhibition of CYP2D6 by Bupropion and Doxepin: Implications for Venlafaxine and Risperidone Metabolism - PubMed
4 hours ago
- #therapeutic drug monitoring
- #CYP2D6 inhibition
- #drug-drug interactions
- Study investigates serum concentration-dependent CYP2D6 inhibition by bupropion (via hydroxybupropion) and doxepin.
- Therapeutic drug monitoring data from inpatients at the University Hospital of Würzburg (2018-2023) were analyzed.
- Hydroxybupropion and doxepin concentrations positively associated with venlafaxine, risperidone, and venlafaxine active moiety levels.
- Half-maximal inhibitory concentration values identified for hydroxybupropion and doxepin.
- Phenoconversion thresholds identified for hydroxybupropion and doxepin affecting venlafaxine and risperidone metabolism.
- Monitoring inhibitor and victim-drug concentrations may help manage clinically relevant CYP2D6-mediated interactions.