The Effects of Digital Health Interventions on Motor Symptoms, Nonmotor Symptoms, and Quality of Life in Patients With Parkinson Disease: Systematic Review and Meta-Analysis of Randomized Controlled T

7 hours ago

Digital health interventions (DHIs) show potential in improving motor and nonmotor symptoms in Parkinson's disease (PD) patients.
A systematic review and meta-analysis included 112 randomized controlled trials with 5594 participants.
Significant improvements were found in motor symptoms (SMD=-0.39) and nonmotor symptoms (SMD=-0.26), including cognitive function (SMD=0.47) and psychiatric symptoms (SMD=-0.42).
No significant improvement was observed in quality of life (SMD=-0.19).
Evidence certainty was very low for quality of life, motor, and psychiatric symptoms, and low for cognitive function and overall nonmotor symptoms.
Age, percentage of female participants, and supervision mode were identified as possible sources of heterogeneity.
The review highlights the need for more robust trials, especially in resource-limited settings, due to high risk of bias and substantial heterogeneity.

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