Fragmentomic liquid biopsy enables early breast cancer detection, molecular subtyping and lymph node assessment - PubMed
5 days ago
- #breast cancer
- #liquid biopsy
- #fragmentomics
- Fragmentomic liquid biopsy (TuFEst) enables early breast cancer detection with 95% sensitivity and 78.3% specificity.
- TuFEst can identify malignancies missed by conventional imaging and supports molecular subtyping (TuFEst-MS) and lymph node status prediction (TuFEst-LN).
- Transcriptomic profiling shows TuFEst-derived cancer scores reflect tumor aggressiveness and immune-related biological programs.
- The study involved 503 breast cancer patients and 289 benign controls across multiple centers.
- Authors Z.L., W.X., and W.L. have competing interests related to OmixScience Co., Ltd. and a patent application.