Renaissance of antiviral CD8+ T cell immunity in vaccination and disease - PubMed
3 hours ago
- #Viral infections
- #CD8+ T cells
- #Vaccines
- CD8+ T cell-based vaccines have shown limited efficacy in clinical trials over the past 20 years.
- Recent findings highlight the importance of CD8+ T cells in controlling acute and chronic viral infections.
- Effective CD8+ T cell responses share features like effector functions and stemness properties against viruses such as SARS-CoV-2 and HIV.
- Advances in immunological and biotechnological tools are opening new avenues for eliciting optimal T cell responses.
- There is renewed optimism for CD8+ T cell-based vaccines and immunotherapies in combating viral threats and persistent infections like HIV-1.