Distinct cerebrospinal fluid profiles of astrocytic aquaporin-4 and GFAP in neuroinflammatory disorders - PubMed
4 hours ago
- #neuroinflammatory-disorders
- #GFAP
- #AQP4
- Aquaporin 4 (AQP4) is a water channel expressed in astrocytic end feet and is suggested as a biomarker in Alzheimer's disease.
- The study investigated CSF AQP4 and GFAP levels in 301 patients with various neuroinflammatory disorders and 98 controls.
- CSF AQP4 levels were elevated in non-immune mediated polyneuropathy (NIP) patients, especially hereditary NIP.
- CSF GFAP was elevated in AQP4 autoantibody positive NMOSD patients but not in AQP4 autoantibody negative NMOSD patients.
- Combining AQP4 and GFAP levels or their ratio did not significantly improve diagnostic discrimination.
- AQP4 shows potential as a biomarker in peripheral neuropathies, while GFAP indicates astrocytic injury in autoantibody positive NMOSD.
- AQP4 and GFAP reflect different astrocytic processes in neurological diseases.