UFMylation: A Key Role in Maintaining Endoplasmic Reticulum Homeostasis - PubMed
5 hours ago
- #Post-translational Modification
- #Endoplasmic Reticulum
- #UFMylation
- UFMylation is a ubiquitin-like post-translational modification system crucial for endoplasmic reticulum (ER) function.
- The process involves key molecular components: UFM1, UBA5, UFC1, UFL1, DDRGK1, and CDK5RAP3.
- UFMylation modulates the ER stress response, balancing adaptive cellular remodeling and apoptotic signaling.
- It facilitates ER-phagy and ribosome-associated quality control to remove stalled ribosomes and damaged ER.
- Dysregulation of UFMylation is linked to diseases with abnormal ER function.
- The review discusses UFMylation's regulatory roles in the ER and its potential involvement in congenital human diseases.