Adhesion GPCR-induced ectocytosis mediates intercellular GPCR signal propagation - PubMed
8 days ago
- #GPCR
- #cell communication
- #extracellular vesicles
- Adhesion GPCRs (aGPCRs) induce the formation of migrasomes and retractosomes, two newly identified extracellular vesicle (EV) subtypes.
- Activated aGPCRs undergo ectocytosis into these EVs and are internalized by receiving cells, leading to de novo G-protein activation.
- Cancer-cell-derived migrasomes transfer aGPCRs like GPR56 to endothelial cells, enhancing angiogenic potential in vitro and in vivo.
- The study reveals a novel mechanism of cell-cell communication through EV-mediated intercellular spread of active GPCRs.