Imaging-based organ-specific aging clock predicts human diseases and mortality - PubMed
4 hours ago
- #biomarkers
- #organ-health
- #aging-clocks
- Imaging-based organ-specific aging clocks predict diseases and mortality.
- Study used 1777 imaging-derived phenotypes (IDPs) from 11,000 healthy participants.
- Assessed biological age of seven organs, linking age gaps to organ-specific diseases and mortality.
- Top IDPs were biomarkers for disease prediction, e.g., dementia (AUC = 0.82).
- Proteomic analysis revealed 966 shared and 507 organ-specific molecular aging signatures.
- Identified key modifiable factors and 14 drug targets for organ-specific aging.
- Imaging-based aging clocks show potential for personalized intervention and treatment.