The Roles of SQSTM1/p62 in Selective Autophagy and Oncogenic Signaling - PubMed
3 hours ago
- #p62
- #cancer
- #autophagy
- Autophagy regulates degradation of misfolded proteins and non-functional organelles.
- Three types of autophagy: macroautophagy, microautophagy, and chaperone-mediated autophagy (CMA).
- SQSTM1/p62 acts as a signaling hub integrating NF-κB, mTORC1, and Keap1-NRF2 pathways.
- p62 is a selective autophagy receptor that binds ubiquitinated cargo for degradation.
- Phase separation of p62 is crucial in autophagy regulation.
- Impaired or excessive autophagy mediated by p62 is linked to cancer development.
- Review focuses on p62's role in autophagy and cancer progression.