TSP-1 interaction with RANK and OPG: implications for bone remodeling and osteolytic bone metastasis - PubMed
4 hours ago
- #bone remodeling
- #osteolytic metastasis
- #TSP-1
- TSP-1 plays a role in bone remodeling and osteolytic bone metastasis.
- A C-terminal fragment of TSP-1, E123CaG, inhibits RANKL-induced osteoclast differentiation.
- E123CaG binds to RANK and OPG, impairing osteoclast signaling and protecting OPG from degradation.
- In vivo, E123CaG reduces osteolytic lesions and prolongs survival in a model of breast cancer bone metastasis.
- The study suggests TSP-1 fragments as a potential mechanism to control bone remodeling in metastasis.