Hallmarks of the ageing lung - 10 years later - PubMed
a day ago
- #chronic lung disease
- #lung aging
- #cellular senescence
- Aging is a major risk factor for chronic lung diseases like COPD, IPF, and lung cancer.
- The review updates key cellular and molecular features of aging that drive lung disease progression.
- Structural and functional changes in aging lungs include reduced elasticity, chronic inflammation, and impaired repair.
- Extracellular matrix (ECM) dysregulation is now recognized as a hallmark of lung aging.
- Environmental exposures (e.g., cigarette smoke, wildfire smoke) accelerate aging via oxidative stress and cellular senescence.
- In lung cancer, aging contributes to genomic instability, immune evasion, and therapy resistance.
- Emerging research explores extracellular vesicles and microbiome changes in lung aging.
- Clinical trials are targeting aging hallmarks (e.g., cellular senescence) to mitigate age-related lung pathology.
- Understanding aging mechanisms could lead to novel diagnostics and therapies for chronic lung diseases.