In Vitro Cytotoxicity Assessment of Leaves of Tieghemella heckelii on Breast (MDA-MB-468), Liver (HepG2), and Prostate (PC3) Cancer Cell Lines - PubMed
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- #Tieghemella heckelii
- #cytotoxicity
- #cancer research
- The study evaluates the in vitro anticancer activities of Tieghemella heckelii leaves on breast (MDA-MB-468), liver (HepG2), and prostate (PC3) cancer cell lines.
- Cancer is a leading cause of death worldwide, with breast, liver, and prostate cancers being highly prevalent.
- Tieghemella heckelii leaves were collected from Ghana, and both aqueous and ethanol extracts were prepared for testing.
- The MTT method was used to determine cell viability, with results showing cytotoxicity against cancer cell lines.
- Ethanolic and aqueous extracts showed similar cytotoxicity for HepG2, with IC50 values around 200 μg/mL.
- The aqueous extract for prostate cancer (PC3) showed the lowest IC50 value and highest selectivity (index of 8).
- Extracts were less cytotoxic against normal (Vero) cell lines, indicating potential selectivity for cancer cells.
- The study concludes that T. heckelii leaves have cytotoxic properties, particularly against prostate and liver cancer cells.
- Further in vivo studies and identification of bioactive compounds are recommended for future research.