Human liver-derived organoids recapitulate Oropouche virus infection and manifestation, enabling antiviral drug discovery - PubMed
12 hours ago
- #liver organoids
- #Oropouche virus
- #antiviral drug discovery
- Oropouche virus (OROV) is a re-emerging arbovirus causing febrile illness and severe complications with no approved treatments.
- Human liver-derived organoids successfully model OROV infection, showing elevated liver enzymes and cellular damage.
- Transcriptomic analysis reveals OROV activates interferon-stimulated genes and cell death pathways in liver organoids.
- Interferon-α treatment suppresses OROV infection, while inhibiting the interferon pathway enhances viral replication.
- Molnupiravir, an antiviral drug, significantly inhibits OROV replication and reduces virus-induced cytopathology.
- Combining molnupiravir with interferon-α shows synergistic antiviral effects, highlighting complementary treatment strategies.