Insight of traditional Chinese medicine in treating pulmonary hypertension: Achievements from 2021 to 2025 - PubMed
5 hours ago
- #Pharmacological Mechanisms
- #Pulmonary Hypertension
- #Traditional Chinese Medicine
- Traditional Chinese Medicine (TCM) shows therapeutic potential for pulmonary hypertension (PH) through multi-target and multi-pathway mechanisms.
- The review covers TCM formulas, extracts, and active components, highlighting their pharmacological mechanisms in treating PH.
- Key experimental models include monocrotaline-induced PAH in vivo and hypoxia-induced in vitro models using PASMCs.
- TCM targets multiple signaling pathways, including NF-κB, PI3K-AKT-mTOR, K+/Ca2+ channels, HIF-2α-Arg-NO, TGF-β1/Smad, JAK2-STAT3, and p53-p21.
- TCM's advantages include alleviating inflammation, oxidative stress, vascular remodeling, and protecting endothelial function.
- TCM is positioned as a promising complementary strategy for managing PH.