Effect of a Nutraceutical Combination on Oxidative Stress Biomarkers in Healthy Subjects and Patients with Alzheimer's Disease - PubMed

3 hours ago

A nutraceutical combination was developed to target oxidative stress and glycation-related biomarkers in Alzheimer's disease (AD) and healthy aging.
The study screened 12 compounds, identifying quercetin, rutin, and genistein as the most effective inhibitors of glycation in a BSA-glucose model.
A 3-month randomized, double-blind, placebo-controlled trial was conducted with 30 older healthy adults and 30 AD patients, split into treatment and placebo groups.
In healthy older adults, the anti-AGE blend significantly reduced serum malondialdehyde (MDA) levels compared to placebo.
In AD patients, the treatment group showed lower post-intervention MDA levels than placebo, and urinary Nε-(carboxymethyl)lysine (CML) levels decreased significantly.
The study concluded that the nutraceutical blend could modulate oxidative stress biomarkers, with MDA reductions in both groups and selective CML decreases in AD patients.
Larger trials with extended biomarker panels and LC-MS/MS confirmation were recommended for further validation.

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