CMTM6 promotes synovial proliferation and macrophage polarization by preventing ubiquitination of TAK1 in rheumatoid arthritis - PubMed
4 hours ago
- #TAK1
- #Rheumatoid Arthritis
- #CMTM6
- CMTM6 is found at increased levels in serum, synovial fluid, and tissues of RA patients.
- Silencing CMTM6 reduces proliferation, migration, and cytokine secretion in FLSs while promoting apoptosis.
- CMTM6 stabilizes TAK1 by preventing its ubiquitin-proteasome degradation, activating TNF/TNFR and NF-κB/MAPK pathways.
- CMTM6 promotes M1-macrophage polarization by increasing pro-inflammatory cytokines in the joint microenvironment.
- AAV-shCmtm6 treatment in CIA mice reduces joint damage and Cmtm6/Tak1 expression, similar to TNF-α antibody effects.
- Targeting CMTM6 could be a potential therapeutic strategy for rheumatoid arthritis.