Beyond inflammation: alarmins as critical drivers of pulmonary fibrosis - PubMed
a day ago
- #type 2 immune response
- #alarmins
- #pulmonary fibrosis
- Pulmonary fibrosis is a chronic respiratory disorder marked by excessive fibrotic tissue in the lungs.
- Epithelial alarmins (TSLP, IL-25, IL-33) play a key role in idiopathic pulmonary fibrosis and connective tissue disease-associated interstitial lung disease.
- Alarmins act as damage-associated molecular patterns, attracting innate and adaptive immune cells, influencing immune responses to fibrosis.
- They regulate fibroblast-macrophage interactions, affecting macrophage polarization and epithelial-mesenchymal transition during lung injury.
- Alarmins activate the type 2 immune network, contributing to profibrotic type 2 immune responses.
- Research into alarmins may lead to new targeted therapies for pulmonary fibrosis.