Pulmonary organoid models demonstrate compositionally driven epithelial plasticity and immune polarization - PubMed
6 hours ago
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- Pulmonary organoid models with varied immune, epithelial, and mesenchymal inputs show composition-dependent epithelial plasticity and macrophage polarization.
- In mesenchyme-rich contexts, crosstalk reinforces inflammatory signaling and stabilizes transitional cell states like Sox9+ stressed progenitors and RAS-like intermediates.
- Immune-dominant inputs favor ATI-like repair and squamous remodeling, while hillock-like cells may act as epithelial orchestrators regulating immune responses.
- Regenerative outcomes are linked to multicellular signaling networks involving stress sensing, immune coordination, and epithelial resilience.
- This model aids in studying milieu-specific regenerative mechanisms and developing strategies to redirect epithelial fate in chronic lung diseases.