Where Do Target Trials Come From? Specifying the Protocol of a Target Trial When Repurposing Data for Causal Inference - PubMed
10 hours ago
- #Observational Data
- #Target Trial
- #Causal Inference
- The target trial protocol is often constrained by the observational data available to investigators.
- Investigators typically develop the target trial protocol iteratively as they learn about the data.
- The final causal question and target trial protocol depend on both the original question and data constraints.
- Prespecification of an emulatable target trial protocol is generally not possible due to necessary adaptations.
- Adaptations raise questions about permissible data examinations, transparent reporting, and rule prespecification.