Harnessing viral strategies to reverse cognitive dysfunction through the integrated stress response - PubMed
3 hours ago
- #integrated stress response
- #cognitive function
- #neurodegeneration
- The integrated stress response (ISR) is crucial for cellular balance and cognitive function.
- Persistent ISR activation due to the PPP1R15B\u2022R658C variant impairs protein synthesis and causes long-term memory deficits in mice.
- DP71L, a viral version of PPP1R15B, acts as a pan-ISR inhibitor, reversing cognitive and synaptic deficits in models of Down syndrome, Alzheimer's disease, aging, and even improving memory in healthy mice.