Nephropathy 1 Formula (N1F) mitigates cisplatin-induced acute kidney injury by inhibiting TAK1-dependent NF-κB signaling - PubMed
7 hours ago
- #acute kidney injury
- #traditional Chinese medicine
- #NF-κB signaling
- Nephropathy 1 Formula (N1F) mitigates cisplatin-induced acute kidney injury (AKI) by inhibiting TAK1-dependent NF-κB signaling.
- N1F is derived from the traditional Chinese medicine prescription Biejia Jian Wan and has been used clinically for renal protection.
- The study evaluated N1F's protective effects against cisplatin-induced AKI, focusing on TAK1-NF-κB signaling and active phytochemical identification.
- N1F improved renal function, reduced tubular injury, and suppressed inflammation and apoptosis in cisplatin-challenged mice.
- Mechanistically, N1F inhibited TAK1, IKKβ, and IKBα phosphorylation, preventing NF-κB p65 nuclear translocation.
- Key bioactive components identified include ginsenosides (Rg1, F2, Rg6) and saikosaponins (D, B2).
- The study concludes that N1F alleviates cisplatin-induced AKI primarily by inhibiting TAK1-NF-κB signaling.