Hepatitis D Virus Pathogenesis: A Sense of Complications - PubMed
4 hours ago
- #Viral Hepatitis
- #HDV Pathogenesis
- #Hepatocellular Carcinoma
- HDV is a satellite RNA virus dependent on HBV, affecting ~12 million people globally.
- It causes the most severe form of chronic viral hepatitis, leading to rapid progression to fibrosis, cirrhosis, liver decompensation, and liver cancer.
- HDV pathogenesis involves virus sensing, innate immune responses, and viral/host interactions that drive inflammation and oncogenic pressure.
- Direct and indirect contributions of HDV accelerate liver cirrhosis and HCC development, leading to its classification as a group 1 carcinogen in 2025.
- There is an urgent need for improved antiviral treatments, HDV screening in HBV patients, and intensified HCC surveillance in chronic HDV cases.