Persistent viral control status is associated with enhanced innate immune responses in people with HIV-1 - PubMed
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- #HIV-1
- #innate immunity
- #viral control
- Persistent viral control in HIV-1 is linked to enhanced innate immune responses.
- HIV controllers show stronger cytokine production and antiviral gene signatures.
- Monocytes from HIV controllers exhibit reduced inflammatory gene expression.
- Persistent controllers have increased trained immunity and epigenetic priming of immune genes.
- Relatives of persistent controllers also display stronger innate immune responses.
- Robust innate immunity may precede HIV infection and aid in viral control.
- Findings suggest new therapeutic approaches targeting innate antiviral responses.