Mesenchymal stem cell-derived exosomes derived from induced pluripotent stem cells ameliorate inflammation and promote mucosal healing via miR-34a-5p in Crohn disease - PubMed
8 hours ago
- #stem cell therapy
- #exosomes
- #Crohn disease
- Mesenchymal stem cell-derived exosomes (MSC-Exos) from induced pluripotent stem cells (iPSCs) show therapeutic potential for Crohn disease (CD).
- iPSC-MSC-Exos reduce inflammation and promote mucosal healing in a TNBS-induced colitis mouse model.
- The exosomes protect colon stem cells, enhance epithelial proliferation, and modulate immune responses by increasing anti-inflammatory cells (Treg, Breg) and decreasing proinflammatory cells (Th1/9/17, TNF-α+).
- miR-34a-5p in iPSC-MSC-Exos plays a key role by targeting PPP2R3A, activating Wnt/β-catenin signaling, and promoting healing.
- Overexpression of miR-34a-5p enhances therapeutic effects, while knockdown abolishes them.
- A single injection of iPSC-MSC-Exos sustains therapeutic effects for 7 days.