Uncovering the dynamics of mucosa-associated microbiota in post-operative recurrence of Crohn's disease - PubMed
4 hours ago
- #Crohn's Disease
- #Post-operative Recurrence
- #Microbiota
- About 50-75% of Crohn's Disease (CD) patients require bowel resection, with frequent postoperative recurrence.
- Study investigates mucosa-associated microbiota dynamics using 16S rRNA and ITS2 sequencing in CD patients post-surgery.
- Microbial signatures, like decreased Faecalibacterium prausnitzii and increased Akkermansia muciniphila, correlate with Rutgeerts score variations.
- Machine learning shows better performance when considering Rutgeerts score as multilevel, not binary.
- Post-surgery, microbiota shows denser network organization in absence of recurrence, with changes in keystone species.
- Findings highlight microbiota's dynamic changes in CD recurrence post-ileal resection.