The CD4+ T cell population partners with Tpex CD8+ T cells to mediate antitumor immunity in the tumor microenvironment - PubMed
3 hours ago
- #tumor microenvironment
- #T cells
- #immunotherapy
- Identified a Th7R CD4+ T cell population, IL-7Rhigh CCR6- Th1-like, partnering with Tpex CD8+ T cells in antitumor immunity.
- Th7R cells express lymphotoxin-β and CXCL13, correlate with high endothelial venules, and co-localize with Tpex in tertiary lymphoid structures.
- Th7R abundance correlates with Tpex numbers in tumor microenvironment and lymph nodes; adoptive transfer increases Tpex in mouse models.
- Intratumoral presence of Th7R and Tpex linked to improved response to neoadjuvant PD-1 blockade therapy in lung and renal cell carcinoma.