Dendrobine ameliorates non-alcoholic fatty liver disease by inhibiting mitochondrial fission through modulation of the Wnt5a/p-CaMKII/p-Drp1 signaling axis - PubMed
3 hours ago
- #Mitochondrial fission
- #NAFLD
- #Dendrobine
- Dendrobine (DDB) from Dendrobium nobile Lindl. (DNL) shows hepatoprotective effects against non-alcoholic fatty liver disease (NAFLD).
- DDB inhibits mitochondrial fission by targeting the Wnt5a/p-CaMKII/p-Drp1 signaling axis, improving lipid metabolism in NAFLD.
- In vivo and in vitro studies confirm DDB reduces liver fat accumulation, serum TG/TC levels, and enhances mitochondrial function.
- RNA-sequencing identifies energy metabolism and noncanonical Wnt signaling as key pathways influenced by DDB in NAFLD treatment.
- Molecular docking and assays reveal DDB binds to Wnt5a, reducing its thermal stability and blocking the Wnt5a-mediated pathway.
- Inhibitors Mdivi-1 (Drp1) and Box5 (Wnt5a) mimic DDB's hepatoprotective effects, validating the mechanism of action.