ESHRE guideline: ovarian stimulation for IVF/ICSI: an update in 2025† - PubMed
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- The ESHRE guideline on ovarian stimulation for IVF/ICSI was updated in 2025, providing 121 recommendations addressing 21 key questions.
- The guideline includes 42 unchanged recommendations from 2019, 4 reworded for clarity, 29 updated based on new evidence, and 46 new recommendations for 2025.
- Recommendations cover pre-stimulation evaluation, pre-treatment therapies, pituitary suppression, ovarian stimulation, monitoring, triggering of final oocyte maturation, luteal support, and prevention of OHSS.
- The guideline also provides 17 recommendations on fertility preservation (oncologic and elective) and oocyte donation.
- Of the evidence-based recommendations, none were supported by high-quality evidence, 6 by moderate-quality, 36 by low-quality, and 148 by very low-quality evidence.
- The guideline emphasizes the need for further research, listing specific research recommendations to promote future studies in ovarian stimulation.
- Several newer interventions lack sufficient evidence, leading to recommendations against their use or classifying them as research-only.
- The guideline was developed by ESHRE, with funding for meetings, literature searches, and dissemination, and all work was provided voluntarily by the guideline group members.
- Disclosures include various financial interests among the authors, such as speaker fees, consulting fees, research grants, and advisory board participation.