Autoimmune neuroinflammation leads to neuronal death via MIF nuclease-mediated parthanatos - PubMed
4 days ago
- #MIF nuclease
- #parthanatos
- #neuroinflammation
- Autoimmune neuroinflammation causes neuronal death via MIF nuclease-mediated parthanatos.
- Parthanatos, a caspase-independent and DNA damage-induced cell death program, contributes to neuron death in the EAE mouse model of neuroinflammation.
- Neurons in affected areas show intracellular signs of the parthanatos cascade during EAE.
- Blocking MIF nuclease activity reduces neuron loss and disease severity in EAE.
- Transcriptomic analysis reveals parthanatos-dependent differences in neuronal response to EAE.
- The study suggests MIF nuclease inhibitors as potential treatments for neurologic disorders.