Chronic inflammation as a driving factor for sarcopenia: an update on pathophysiology and future therapeutic targets - PubMed
a day ago
- #aging
- #sarcopenia
- #chronic-inflammation
- Sarcopenia is an age-related decline in muscle mass, strength, and function, impacting older adults' quality of life.
- Chronic inflammation contributes to sarcopenia via cellular senescence, oxidative stress, mitochondrial dysfunction, and gut microbiota dysbiosis.
- Obesity exacerbates sarcopenia, leading to sarcopenic obesity, which worsens muscle loss and functional impairment.
- Interventions like exercise, nutritional supplementation, and combined approaches improve muscle mass and reduce inflammation.
- Anti-inflammatory agents and treatments targeting inflammatory pathways show promise in managing sarcopenia.
- Key inflammatory cytokines (CRP, IL-6, TNF-α) regulate muscle protein metabolism and may serve as biomarkers.
- Understanding inflammation's role in sarcopenia aids in developing early diagnostics and targeted therapies.