Genomic characterization of colistin heteroresistance in Acinetobacter baumannii: Evidence for lpxD deletion and collateral sensitivity - PubMed
3 hours ago
- #lpxD deletion
- #colistin heteroresistance
- #Acinetobacter baumannii
- Study focused on colistin heteroresistance (CHR) in Acinetobacter baumannii bloodstream isolates.
- 267 A. baumannii isolates were analyzed from a tertiary care hospital in Türkiye (2014-2018).
- 13.9% of isolates were colistin-resistant, and 32.2% showed CHR via population analysis profiling (PAP).
- Genomic analysis of a heteroresistant strain (A325) revealed a partial lpxD gene deletion in the resistant subpopulation.
- Colistin-resistant subpopulation showed sensitivity to tetracyclines, macrolides, and aminoglycosides, unlike the susceptible main population.
- Findings suggest LPS-related alterations (via lpxD deletion) may contribute to CHR and highlight collateral sensitivity patterns.