A neuropeptide regulates cell non-autonomous protein homeostasis - PubMed
10 hours ago
- #C. elegans
- #neuropeptide
- #proteostasis
- Glial UPRER activation in C. elegans increases specific neuropeptides, including FLP-17.
- FLP-17, acting partially through EGL-6 receptor, induces cell non-autonomous UPRER and stress resistance.
- XBP-1 and PERK are both required for maximal FLP-17-induced UPRER, but only XBP-1 is essential for ER stress resistance.
- The study identifies FLP-17 as a key mediator coordinating organismal proteostasis via a sensory-metabolic circuit.