Identification and characterization of dietary antigens in oral tolerance - PubMed
4 days ago
- #dietary antigens
- #oral tolerance
- #Treg cells
- Dietary antigens, particularly seed storage proteins, are key in oral tolerance.
- Epitopes from maize protein alpha-zein are major targets of intestinal Treg cells.
- Zein-specific Treg cells develop during weaning and suppress immune responses.
- These Treg cells constitute up to 2% of the peripheral Treg cell pool.
- Prior dietary exposure to these antigens moderates inflammatory responses.