Cytosolic DNA structures produced by mismatch repair deficiency coordinate anti-tumor immunity in colorectal cancer - PubMed
9 hours ago
- #immunotherapy
- #colorectal cancer
- #cGAS/STING
- MSI subtype colorectal cancer (CRC) patients have better prognosis and immunotherapy response due to enhanced cytotoxic T cell responses.
- MSI cyDNA is enriched in G-quadruplexes, improving cGAS/STING pathway activation and CD8+ T cell responses.
- Micronuclei are less effective in anti-tumor immunity and instead promote Treg activation and IL-10 production.
- Specific cyDNA structures play a crucial role in anti-tumor immunity, offering insights for therapeutic cGAS/STING agonists.
- Findings could improve treatment for poorly immunogenic tumors like CIN CRCs.