Dysregulation of macrophage lipid metabolism underlies intracellular bacterial neuroinvasion - PubMed
3 hours ago
- #macrophage
- #lipid metabolism
- #neuroinvasion
- A CD36+ Fabp4+ Pparg+ macrophage subset facilitates bacterial brain penetration without disrupting the blood-brain barrier.
- These macrophages have abundant protrusions and adhesion molecules, resisting shear stress and adhering to endothelial cells.
- Dysregulated lipid metabolism during neuroinvasion involves β-hydroxybutyrate promoting CD36+ macrophage differentiation and survival.
- Ketogenesis worsens bacterial neuroinvasion symptoms, which can be mitigated by glucose supplementation.
- Intracellular bacteria exploit reprogrammed macrophages to access the brain, indicating glycolipid metabolic homeostasis as a therapeutic target.