Activated hepatic stellate cells maintain liver bile acid homeostasis through paracrine FGF10/FGFR2 signaling - PubMed
3 hours ago
- #Cholestasis
- #Bile Acid Homeostasis
- #Hepatic Stellate Cells
- Activated hepatic stellate cells (aHSCs) secrete FGF10, inhibiting CYP7A1 expression in hepatocytes via paracrine signaling to regulate bile acid homeostasis.
- The FGF10/FGFR2 axis activates PAK1/ERK/JNK signaling in hepatocytes, reducing primary bile acid synthesis and alleviating cholestatic liver injury.
- In diet-induced MASH, FGF10 affects bile acid metabolism without significantly altering steatosis or fibrosis, highlighting its specific role in metabolic regulation.