Platelets induce VISTA expression and modulate the ovarian tumor microenvironment - PubMed
5 hours ago
- #ovarian cancer
- #VISTA
- #platelets
- Platelets upregulate VISTA expression in myeloid and tumor cells, promoting an immunosuppressive tumor microenvironment (TME) in ovarian cancer.
- Elevated VISTA levels correlate with higher platelet counts and poorer clinical outcomes in ovarian cancer patients.
- Platelet depletion in mouse models reduces VISTA expression and slows tumor growth.
- Blocking PD-L1 leads to increased VISTA expression, suggesting tumors may use VISTA to evade PD-L1-directed therapies.
- Targeting platelet activity and VISTA could enhance immunotherapy effectiveness in ovarian cancer.