Memory T cell aging and rejuvenation - PubMed
5 hours ago
- #T cell aging
- #immune rejuvenation
- #memory T cells
- Aging reshapes T cell immunity, leading to reduced naive T cell diversity and altered memory hierarchies.
- This results in a constrained repertoire with weakened protection against new infections, cancers, and poorer vaccine responses.
- Decline varies widely among individuals, indicating a shift favoring memory persistence over plasticity.
- Aging affects memory T cells through repertoire contraction, differentiation changes, and altered metabolic, transcriptional, and epigenetic states.
- Chronic inflammation, antigen persistence, and niche remodeling drive dysfunction or resilience in memory T cells.
- Strategies to rejuvenate T cell immunity during aging aim to preserve adaptive competence across lifespan.