MicroRNA-128-3p Deficiency Alleviates Bone Loss in Age-Related Osteoporosis via Activation of Canonical Wnt Signaling - PubMed
7 hours ago
- #osteoporosis
- #miR-128-3p
- #Wnt signaling
- miR-128-3p increases with age in human bone and negatively correlates with bone formation.
- Deletion of miR-128-3p in osteoblasts increases bone mass and osteoblastogenesis.
- miR-128-3p regulates osteoblast differentiation via Dvl2-mediated canonical Wnt signaling.
- Osteoblastic miR-128-3p deficiency prevents age-related bone loss in mice.
- Findings suggest miR-128-3p as a potential therapeutic target for age-related osteoporosis.