Identification of ephrin-A1-EphA2 signalling as a potential target for fracture prevention - PubMed
9 hours ago
- #osteoporosis
- #bone-fracture
- #therapeutic-target
- Ephrin-A1-EphA2 signalling identified as a novel target for preventing osteoporotic fractures.
- Mendelian randomization and colocalization reveal nine circulating proteins linked to forearm fracture risk, including known bone-related proteins and novel protective factor ephrin-A1.
- Ephrin-A1 increases bone mineral density, suggesting a mechanism for fracture protection.
- 3D DeepBone technique shows ephrin-A1 on endothelial cells interacts with EphA2 on osteoblasts at the bone surface.
- Findings support ephrin-A1-EphA2 signalling as a potential therapeutic target to strengthen bone and reduce fracture risk.