Entadamide A-β-D-glucopyranoside Attenuates Psoriatic Dermatitis by Restoring Keratinocyte Homeostasis and Suppressing Neutrophil Extracellular Traps - PubMed
4 hours ago
- #traditional Chinese medicine
- #psoriasis
- #anti-inflammatory
- Entadamide A-β-D-glucopyranoside (EA) from Entada phaseoloides seeds shows therapeutic potential for psoriasis.
- EA alleviates psoriasiform dermatitis by reducing epidermal hyperplasia, scaling, and immune cell infiltration.
- EA suppresses keratinocyte hyperproliferation and restores differentiation markers like keratin 1.
- EA inhibits pro-inflammatory cytokines (IL-36, IL-1β, IL-6, TNF-α, HMGB1) and neutrophil extracellular trap (NET) formation.
- Molecular docking suggests EA binds to IL-36R and P2X7R, inhibiting NLRP3 inflammasome activation.
- EA demonstrates potential as a therapeutic agent derived from traditional Chinese medicine for psoriasis.