Research on epicardial adipose tissue as a metabolic therapeutic target in AF: focus on GLP-1 receptor agonists - PubMed
4 hours ago
- #GLP-1 receptor agonists
- #epicardial adipose tissue
- #atrial fibrillation
- Epicardial adipose tissue (EAT) is a metabolically active fat depot linked to the myocardium and is a key mediator in atrial fibrillation (AF), especially in obesity and diabetes.
- Pathological EAT expansion promotes AF through pro-inflammatory and pro-fibrotic cytokine secretion, extracellular vesicle release, and modulation of local electrophysiology.
- GLP-1 receptor agonists (GLP-1RAs) show cardioprotective effects, potentially reducing EAT volume, inflammation, and fibrosis, and improving AF susceptibility.
- GLP-1 receptors are present in human EAT and atrial tissue, suggesting a direct therapeutic role in AF management.
- Evidence from studies supports GLP-1RAs in reducing AF risk, but further research is needed to clarify drug-specific effects and mechanisms.
- Targeting EAT via GLP-1RAs could disrupt the obesity-diabetes-AF axis, but challenges remain in standardizing EAT assessment and understanding response variability.