Lymphadenectomy in early-stage ovarian cancer: is there still a role? - PubMed
3 hours ago
- #Surgical Staging
- #Ovarian Cancer
- #Lymphadenectomy
- The role of systematic lymphadenectomy in early-stage ovarian cancer is controversial due to lack of high-quality evidence.
- No therapeutic benefit has been confirmed for systematic lymphadenectomy in early-stage ovarian cancer.
- Lymphadenectomy may improve progression-free survival but not overall survival, except in clear cell ovarian cancer.
- Systematic lymphadenectomy helps identify occult nodal metastases (9% to 30% across series).
- Decision to perform lymphadenectomy should be individualized based on histology, tumor grade, stage, and biomarkers.
- Guidelines recommend lymphadenectomy for high-grade tumors but suggest omission in low-grade endometrioid and mucinous subtypes.
- Emerging approaches like sentinel lymph node biopsy and AI-assisted imaging may improve staging accuracy.