Radiation therapy management in BRCA1/2 carriers diagnosed with early breast cancer: An international cohort study - PubMed
6 hours ago
- #Radiation Therapy
- #BRCA
- #Breast Cancer
- This study compares breast-conserving surgery plus radiation therapy (BCS+RT) with mastectomy in young BRCA carriers.
- Overall survival and breast cancer-free interval were similar between BCS+RT and mastectomy alone.
- BCS+RT was associated with a higher risk of second primary breast cancer events compared to mastectomy alone.
- The increased risk of second events was more pronounced in BRCA1 carriers and stage III disease.
- The findings support individualized treatment decisions within a multidisciplinary framework.