Single-cell insights into trophoblast heterogeneity and adaptive dysfunction in selective fetal growth restriction - PubMed
3 hours ago
- #single-cell RNA sequencing
- #trophoblast heterogeneity
- #selective fetal growth restriction
- Single-cell RNA sequencing reveals trophoblast heterogeneity in selective fetal growth restriction (sFGR).
- Growth-restricted placentas show a transition from VCT_TP63 to a metabolically reprogrammed VCT_LDHA phenotype.
- Trajectory analysis indicates diminished syncytial precursors, suggesting impaired fusion capacity.
- Immune profiling identifies depleted TREM2+ Hofbauer macrophages and expanded interferon-responsive NK cells.
- Enhanced IFNG-IFNGR1-STAT1 signaling between VCT_LDHA and immune cells is observed.
- Weakened VCT_TP63-stromal crosstalk is noted in sFGR placentas.
- The study highlights a maladaptive triad of metabolic stress, inflammation, and structural disintegration in sFGR.