Fibro-Adipogenic Progenitors Regulate Orofacial Neuromuscular Junction Regeneration via Myostatin - PubMed
19 hours ago
- #myostatin
- #muscle regeneration
- #neuromuscular junction
- The study compares neuromuscular junction (NMJ) regeneration in orofacial (masseter) and limb (tibialis anterior) muscles after freeze injury, finding that masseter muscles show poorer NMJ regeneration and more fibrosis.
- Fibro-adipogenic progenitors (FAPs) from masseter muscles inhibit postsynaptic acetylcholine receptor (AChR) clustering and NMJ regeneration, with transplantation experiments showing reduced AChRs in recipient muscles.
- RNA-seq identifies myostatin (Mstn) as a key molecule upregulated in masseter FAPs; in vitro and in vivo experiments demonstrate that reducing Mstn enhances AChR clustering and NMJ regeneration.