TRUE-MOGAD Score: A Novel Scoring System to Identify MOGAD Among Positive MOG-IgG Test Results - PubMed
10 hours ago
- #MOGAD
- #Autoimmune Neurology
- #Diagnostic Score
- Researchers developed the TRUE-MOGAD scoring system to differentiate true MOG antibody-associated disease (MOGAD) from false-positive MOG-IgG test results.
- The score incorporates clinical, imaging, and laboratory factors such as high MOG-IgG titers, relapsing optic neuritis, young age at onset, encephalitis phenotype, supportive MRI features, absence of oligoclonal bands, and lesion resolution.
- Internal and external validation showed high diagnostic accuracy, with area under the curve (AUC) values above 0.97, indicating strong predictive performance for MOGAD diagnosis.